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dock7 gene  (MedGen Inc)

 
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    Structured Review

    MedGen Inc dock7 gene
    The association between the <t> DOCK7 </t> , PCSK9 and GALNT2 polymorphisms with hypercholesterolaemia
    Dock7 Gene, supplied by MedGen Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/dock7 gene/product/MedGen Inc
    Average 90 stars, based on 1 article reviews
    dock7 gene - by Bioz Stars, 2026-05
    90/100 stars

    Images

    1) Product Images from "Association of the variants and haplotypes in the DOCK 7, PCSK 9 and GALNT 2 genes and the risk of hyperlipidaemia"

    Article Title: Association of the variants and haplotypes in the DOCK 7, PCSK 9 and GALNT 2 genes and the risk of hyperlipidaemia

    Journal: Journal of Cellular and Molecular Medicine

    doi: 10.1111/jcmm.12713

    The association between the DOCK7 , PCSK9 and GALNT2 polymorphisms with hypercholesterolaemia
    Figure Legend Snippet: The association between the DOCK7 , PCSK9 and GALNT2 polymorphisms with hypercholesterolaemia

    Techniques Used:

    The association between the DOCK7 , PCSK9 and GALNT2 polymorphisms with hypertriglyceridaemia
    Figure Legend Snippet: The association between the DOCK7 , PCSK9 and GALNT2 polymorphisms with hypertriglyceridaemia

    Techniques Used:

    Association between the genotypes of DOCK7 , PCSK9 and GALNT2 SNPs and serum lipid levels in the hypercholesterolaemic and non‐hypercholesterolaemic individuals
    Figure Legend Snippet: Association between the genotypes of DOCK7 , PCSK9 and GALNT2 SNPs and serum lipid levels in the hypercholesterolaemic and non‐hypercholesterolaemic individuals

    Techniques Used:

    Association between the genotypes of DOCK7 , PCSK9 and GALNT2 SNPs and serum lipid levels in the hypertriglyceridaemic and non‐hypertriglyceridaemic individuals
    Figure Legend Snippet: Association between the genotypes of DOCK7 , PCSK9 and GALNT2 SNPs and serum lipid levels in the hypertriglyceridaemic and non‐hypertriglyceridaemic individuals

    Techniques Used:

    The association between the DOCK7, PCSK9 and GALNT2 haplotypes and hypercholesterolaemia/hypertriglyceridaemia
    Figure Legend Snippet: The association between the DOCK7, PCSK9 and GALNT2 haplotypes and hypercholesterolaemia/hypertriglyceridaemia

    Techniques Used: Control



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    Image Search Results


    (A) Schematic of the Dock7 wild type (+) and Dock7 exons 3–4 deletion ( Dock7-em2) transgenic allele. Image created with BioRender.com. (B) Predicted translation of the Dock7+ and Dock7-em2 alleles. Image created with BioRender.com. (C) Representative images of Dock7 +/+ , Dock7 +/em2 , and Dock7 em2/em2 mice.

    Journal: bioRxiv

    Article Title: Deletion of Dock7 Exons 3 and 4 Results in Reduced Trabecular Microarchitecture and a Decrease in Mineralization

    doi: 10.64898/2025.12.31.696872

    Figure Lengend Snippet: (A) Schematic of the Dock7 wild type (+) and Dock7 exons 3–4 deletion ( Dock7-em2) transgenic allele. Image created with BioRender.com. (B) Predicted translation of the Dock7+ and Dock7-em2 alleles. Image created with BioRender.com. (C) Representative images of Dock7 +/+ , Dock7 +/em2 , and Dock7 em2/em2 mice.

    Article Snippet: Dock7 exons 3–4 levels were quantified using a TaqMan gene expression assay containing primers that span across Dock7 exons 3–4 (Thermo Fisher, Mm01259842_g1, 4351372) and TaqMan Fast Advanced Master Mix (Thermo Fisher, 4444556).

    Techniques: Transgenic Assay

    (A) RNA expression of Dock7 exons 3–4, exons 11–12, and exons 34–35 was analyzed in BMSCs differentiated for 7 days in osteogenic media. Points represent individual replicates for all 3 experiments. (B) Quantitative protein analysis of DOCK7 peptides was performed by mass spectrometry in BMSC isolated from Dock7 +/+ and Dock7 em2/em2 mice. N=2 mice/group. Points represent replicates from all mice. (C) DOCK7 peptides were detected by mass spectrometry and used to quantify total DOCK7 levels. High confidence (green), medium confidence (yellow), and low confidence (red) DOCK7 peptides are indicated. The protein sequence corresponding to DOCK7 exons 3–4, the DHR1 domain, and the DHR2 domain is underlined and labeled.

    Journal: bioRxiv

    Article Title: Deletion of Dock7 Exons 3 and 4 Results in Reduced Trabecular Microarchitecture and a Decrease in Mineralization

    doi: 10.64898/2025.12.31.696872

    Figure Lengend Snippet: (A) RNA expression of Dock7 exons 3–4, exons 11–12, and exons 34–35 was analyzed in BMSCs differentiated for 7 days in osteogenic media. Points represent individual replicates for all 3 experiments. (B) Quantitative protein analysis of DOCK7 peptides was performed by mass spectrometry in BMSC isolated from Dock7 +/+ and Dock7 em2/em2 mice. N=2 mice/group. Points represent replicates from all mice. (C) DOCK7 peptides were detected by mass spectrometry and used to quantify total DOCK7 levels. High confidence (green), medium confidence (yellow), and low confidence (red) DOCK7 peptides are indicated. The protein sequence corresponding to DOCK7 exons 3–4, the DHR1 domain, and the DHR2 domain is underlined and labeled.

    Article Snippet: Dock7 exons 3–4 levels were quantified using a TaqMan gene expression assay containing primers that span across Dock7 exons 3–4 (Thermo Fisher, Mm01259842_g1, 4351372) and TaqMan Fast Advanced Master Mix (Thermo Fisher, 4444556).

    Techniques: RNA Expression, Mass Spectrometry, Isolation, Sequencing, Labeling

    Journal: bioRxiv

    Article Title: Deletion of Dock7 Exons 3 and 4 Results in Reduced Trabecular Microarchitecture and a Decrease in Mineralization

    doi: 10.64898/2025.12.31.696872

    Figure Lengend Snippet:

    Article Snippet: Dock7 exons 3–4 levels were quantified using a TaqMan gene expression assay containing primers that span across Dock7 exons 3–4 (Thermo Fisher, Mm01259842_g1, 4351372) and TaqMan Fast Advanced Master Mix (Thermo Fisher, 4444556).

    Techniques:

    Body composition was measured by DXA analysis in male and female Dock7 em2/em2 mice and compared to Dock7 +/+ control mice. Data was analyzed by 2-way ANOVA and Holm-Šídák’s test for post-hoc analysis. N=14–15 mice/group. Points represent each mouse.

    Journal: bioRxiv

    Article Title: Deletion of Dock7 Exons 3 and 4 Results in Reduced Trabecular Microarchitecture and a Decrease in Mineralization

    doi: 10.64898/2025.12.31.696872

    Figure Lengend Snippet: Body composition was measured by DXA analysis in male and female Dock7 em2/em2 mice and compared to Dock7 +/+ control mice. Data was analyzed by 2-way ANOVA and Holm-Šídák’s test for post-hoc analysis. N=14–15 mice/group. Points represent each mouse.

    Article Snippet: Dock7 exons 3–4 levels were quantified using a TaqMan gene expression assay containing primers that span across Dock7 exons 3–4 (Thermo Fisher, Mm01259842_g1, 4351372) and TaqMan Fast Advanced Master Mix (Thermo Fisher, 4444556).

    Techniques: Control

    Osteogenic differentiation was assessed in BMSCs that were isolated from Dock7 +/+ and Dock7 em2/em2 mice after 7 days of osteogenic differentiation. (A) Representative image of von Kossa and alkaline phosphatase staining. (B) Expression of the osteoblast-related genes Runx2 , AlpI , and Bglap . Points represent individual replicates for all 3 experiments.

    Journal: bioRxiv

    Article Title: Deletion of Dock7 Exons 3 and 4 Results in Reduced Trabecular Microarchitecture and a Decrease in Mineralization

    doi: 10.64898/2025.12.31.696872

    Figure Lengend Snippet: Osteogenic differentiation was assessed in BMSCs that were isolated from Dock7 +/+ and Dock7 em2/em2 mice after 7 days of osteogenic differentiation. (A) Representative image of von Kossa and alkaline phosphatase staining. (B) Expression of the osteoblast-related genes Runx2 , AlpI , and Bglap . Points represent individual replicates for all 3 experiments.

    Article Snippet: Dock7 exons 3–4 levels were quantified using a TaqMan gene expression assay containing primers that span across Dock7 exons 3–4 (Thermo Fisher, Mm01259842_g1, 4351372) and TaqMan Fast Advanced Master Mix (Thermo Fisher, 4444556).

    Techniques: Isolation, Staining, Expressing

    The association between the DOCK7 , PCSK9 and GALNT2 polymorphisms with hypercholesterolaemia

    Journal: Journal of Cellular and Molecular Medicine

    Article Title: Association of the variants and haplotypes in the DOCK 7, PCSK 9 and GALNT 2 genes and the risk of hyperlipidaemia

    doi: 10.1111/jcmm.12713

    Figure Lengend Snippet: The association between the DOCK7 , PCSK9 and GALNT2 polymorphisms with hypercholesterolaemia

    Article Snippet: DOCK7 (gene ID: 85440, MedGen: CN189147, OMIM: 615859) is located on chromosome 1p31.3 (Exon count: 53) and encodes for DOCK7 protein.

    Techniques:

    The association between the DOCK7 , PCSK9 and GALNT2 polymorphisms with hypertriglyceridaemia

    Journal: Journal of Cellular and Molecular Medicine

    Article Title: Association of the variants and haplotypes in the DOCK 7, PCSK 9 and GALNT 2 genes and the risk of hyperlipidaemia

    doi: 10.1111/jcmm.12713

    Figure Lengend Snippet: The association between the DOCK7 , PCSK9 and GALNT2 polymorphisms with hypertriglyceridaemia

    Article Snippet: DOCK7 (gene ID: 85440, MedGen: CN189147, OMIM: 615859) is located on chromosome 1p31.3 (Exon count: 53) and encodes for DOCK7 protein.

    Techniques:

    Association between the genotypes of DOCK7 , PCSK9 and GALNT2 SNPs and serum lipid levels in the hypercholesterolaemic and non‐hypercholesterolaemic individuals

    Journal: Journal of Cellular and Molecular Medicine

    Article Title: Association of the variants and haplotypes in the DOCK 7, PCSK 9 and GALNT 2 genes and the risk of hyperlipidaemia

    doi: 10.1111/jcmm.12713

    Figure Lengend Snippet: Association between the genotypes of DOCK7 , PCSK9 and GALNT2 SNPs and serum lipid levels in the hypercholesterolaemic and non‐hypercholesterolaemic individuals

    Article Snippet: DOCK7 (gene ID: 85440, MedGen: CN189147, OMIM: 615859) is located on chromosome 1p31.3 (Exon count: 53) and encodes for DOCK7 protein.

    Techniques:

    Association between the genotypes of DOCK7 , PCSK9 and GALNT2 SNPs and serum lipid levels in the hypertriglyceridaemic and non‐hypertriglyceridaemic individuals

    Journal: Journal of Cellular and Molecular Medicine

    Article Title: Association of the variants and haplotypes in the DOCK 7, PCSK 9 and GALNT 2 genes and the risk of hyperlipidaemia

    doi: 10.1111/jcmm.12713

    Figure Lengend Snippet: Association between the genotypes of DOCK7 , PCSK9 and GALNT2 SNPs and serum lipid levels in the hypertriglyceridaemic and non‐hypertriglyceridaemic individuals

    Article Snippet: DOCK7 (gene ID: 85440, MedGen: CN189147, OMIM: 615859) is located on chromosome 1p31.3 (Exon count: 53) and encodes for DOCK7 protein.

    Techniques:

    The association between the DOCK7, PCSK9 and GALNT2 haplotypes and hypercholesterolaemia/hypertriglyceridaemia

    Journal: Journal of Cellular and Molecular Medicine

    Article Title: Association of the variants and haplotypes in the DOCK 7, PCSK 9 and GALNT 2 genes and the risk of hyperlipidaemia

    doi: 10.1111/jcmm.12713

    Figure Lengend Snippet: The association between the DOCK7, PCSK9 and GALNT2 haplotypes and hypercholesterolaemia/hypertriglyceridaemia

    Article Snippet: DOCK7 (gene ID: 85440, MedGen: CN189147, OMIM: 615859) is located on chromosome 1p31.3 (Exon count: 53) and encodes for DOCK7 protein.

    Techniques: Control

    Validation of microarray by QPCR

    Journal: Arthritis Research & Therapy

    Article Title: The influence of the NOD Nss1 / Idd5 loci on sialadenitis and gene expression in salivary glands of congenic mice

    doi: 10.1186/ar2300

    Figure Lengend Snippet: Validation of microarray by QPCR

    Article Snippet: The 10 assays used for QPCR validation were Ccl19 (Mm00839967_g1), Cd19 (Mm00515420_m1), Egf (Mm00438696_m1), Klk9 ( Egf-bp ) (Mm00658534_mH), Ltb (Mm00434774_g1), Sell (Mm00441291_m1), Zap70 (Mm00494255_m1), Stat1 (Mm00439518_m1), Dock7 (Mm01259863_m1) and Fas (Mm00433237_m1).

    Techniques: Biomarker Discovery, Microarray

    Differentially expressed genes in the two congenic intervals

    Journal: Arthritis Research & Therapy

    Article Title: The influence of the NOD Nss1 / Idd5 loci on sialadenitis and gene expression in salivary glands of congenic mice

    doi: 10.1186/ar2300

    Figure Lengend Snippet: Differentially expressed genes in the two congenic intervals

    Article Snippet: The 10 assays used for QPCR validation were Ccl19 (Mm00839967_g1), Cd19 (Mm00515420_m1), Egf (Mm00438696_m1), Klk9 ( Egf-bp ) (Mm00658534_mH), Ltb (Mm00434774_g1), Sell (Mm00441291_m1), Zap70 (Mm00494255_m1), Stat1 (Mm00439518_m1), Dock7 (Mm01259863_m1) and Fas (Mm00433237_m1).

    Techniques: Membrane, Binding Assay, Glycoproteomics

    Differentially expressed cytokine and chemokine genes

    Journal: Arthritis Research & Therapy

    Article Title: The influence of the NOD Nss1 / Idd5 loci on sialadenitis and gene expression in salivary glands of congenic mice

    doi: 10.1186/ar2300

    Figure Lengend Snippet: Differentially expressed cytokine and chemokine genes

    Article Snippet: The 10 assays used for QPCR validation were Ccl19 (Mm00839967_g1), Cd19 (Mm00515420_m1), Egf (Mm00438696_m1), Klk9 ( Egf-bp ) (Mm00658534_mH), Ltb (Mm00434774_g1), Sell (Mm00441291_m1), Zap70 (Mm00494255_m1), Stat1 (Mm00439518_m1), Dock7 (Mm01259863_m1) and Fas (Mm00433237_m1).

    Techniques: